Evaluation of the Effects of Astragalus membranaceus on the Pharmacokinetics of Pemetrexed Disodium and Gemcitabine in Rats by a Simple High-Performance Liquid Chromatography/UV Method

Table 1

Precision and accuracy of pemetrexed disodium and gemcitabine determination in rat plasma ().

Analytes	Spiked concentration (μg/mL)	Intraday precision and accuracy		Interday precision and accuracy
		Accuracy (%)	Precision (RSD, %)	Accuracy (%)	Precision (RSD, %)
Pemetrexed disodium	1	92.42	1.55	93.63	1.54
	200	109.29	2.00	105.72	4.34
	400	95.98	0.90	93.46	4.11
Gemcitabine	1	94.68	1.88	99.18	8.01
	200	98.61	1.41	94.93	3.44
	400	99.49	0.65	97.76	1.69