Evaluation of the Effects of Astragalus membranaceus on the Pharmacokinetics of Pemetrexed Disodium and Gemcitabine in Rats by a Simple High-Performance Liquid Chromatography/UV Method

Table 3

Pharmacokinetic (PK) parameters of pemetrexed disodium and gemcitabine in rats (mean ± SD, ).

PK parameters	Unit	Pemetrexed disodium		Gemcitabine
		Group I	Group II	Group III	Group IV
AUC(0−t)	mg/L·min	24310.66 ± 6780.89	18083.12 ± 2679.02	15747.12 ± 497.11	12312.41 ± 594.21
AUC(0−∞)	mg/L·min	24368.58 ± 6849.85	18083.84 ± 2678.89	15976.18 ± 511.33	12489.59 ± 682.01
MRT	min	42.49 ± 18.02	36.20 ± 1.45	97.83 ± 5.82	84.37 ± 2.79
T1/2z	min	38.30 ± 7.64	25.03 ± 1.18	80.21 ± 1.22	80.00 ± 10.65
C2min	mg/L	621.28 ± 154.5	596.11 ± 117.83	171.96 ± 9.96	164.87 ± 8.28
Vd	L/kg	0.36 ± 0.09	0.31 ± 0.05	2.18 ± 0.89	2.78 ± 0.34
Cl	L/min/kg	0.0067 ± 0.0018	0.0087 ± 0.0011	0.019 ± 0.0067	0.024 ± 0.0013