Simultaneous Determination of 15 Sulfonate Ester Impurities in Phentolamine Mesylate, Amlodipine Besylate, and Tosufloxacin Tosylate by LC-APCI-MS/MS

Figure 2

(a) The 15 analytes in methanol containing 0.25% HAc (80 ng/mL): peaks 1–5, methyl, ethyl, propyl, isopropyl, and butyl methanesulfonate, respectively; peaks 6–10, methyl, ethyl, propyl, isopropyl, and butyl benzenesulfonate, respectively; and peaks 11–15, methyl, ethyl, propyl, isopropyl, and butyl p-toluenesulfonate, respectively. (b) An MRM chromatogram of the extracted drug product of phentolamine mesylate. (c) An MRM chromatogram of the 15 analytes (50 ng/mL methanesulfonate esters and 10 ng/mL benzenesulfonate and p-toluenesulfonate esters) presented in the phentolamine mesylate tablet.

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(b)

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