Comparative Pharmacokinetic Studies of Four Ginsenosides in Rat Plasma by UPLC-MS/MS after Oral Administration of Panax quinquefolius-Acorus gramineus and Panax quinquefolius Extracts

Table 3

Precision and accuracy for the determination of the ginsenosides in rat plasma.

Compounds	Spiked concentration (ng/mL)	Measured (ng/mL)	Intraday precision RSD (%)	Interday precision RSD (%)	Accuracy Re (%)
Rb1	3.6	3.3 ± 0.21	12.01	13.73	3.40
	7.2	7.1 ± 0.10	7.55	7.02	−1.22
	142.4	143.1 ± 1.05	6.83	4.57	4.39
	911.4	910.9 ± 0.05	9.57	5.44	6.01
Rb2	1.6	1.7 ± 0.13	13.54	14.01	−1.84
	3.2	3.2 ± 0.05	14.32	14.48	−5.32
	62.5	61.5 ± 0.18	6.82	8.07	3.76
	400.0	399.3 ± 0.25	9.97	9.19	5.37
Rd	1.2	1.3 ± 0.17	14.61	10.22	4.20
	2.4	2.7 ± 0.21	13.57	13.74	−2.10
	48.8	49.5 ± 0.17	10.83	7.22	−4.05
	312.2	311.9 ± 0.26	6.39	6.04	5.01
Re	2.5	2.5 ± 0.07	11.65	10.34	−6.94
	5.0	4.89 ± 0.26	14.63	14.57	3.29
	98.6	98.3 ± 0.04	8.77	11.22	7.35
	630.8	632.8 ± 0.31	12.08	7.58	−4.10