Comparative Pharmacokinetic Studies of Four Ginsenosides in Rat Plasma by UPLC-MS/MS after Oral Administration of Panax quinquefolius-Acorus gramineus and Panax quinquefolius Extracts

Table 5

Stability of the ginsenosides in rat plasma.

Compound	Spiked concentration (ng/mL)	Mean concentration (ng/mL)	Re (%)			Recovery (%)
			Short term	Freeze-thaw cycles	Postpreparation	Short term	Freeze-thaw cycles	Postpreparation
Rb1	7.2	7.1	−7.55	−6.90	6.86	96.32	97.66	101.85
	142.4	141.2	7.95	−4.48	9.35	100.48	95.35	101.65
	911.4	910.5	7.53	7.75	−6.47	101.65	101.95	96.10
Rb2	3.2	3.0	−9.70	−9.69	−9.72	93.67	94.21	93.37
	62.5	61.6	−2.12	6.77	2.39	95.33	100.41	99.94
	400.0	402.9	7.11	9.36	7.90	98.74	103.82	99.63
Rd	2.4	2.4	8.64	−11.93	4.43	102.66	97.24	100.10
	48.8	49.7	10.24	8.87	9.98	103.61	100.20	101.71
	312.2	310.2	7.35	8.12	−7.02	101.27	102.00	94.81
Re	5.0	5.1	−10.71	7.33	8.54	97.30	104.07	104.63
	98.6	95.5	12.11	7.53	8.92	99.25	94.12	97.21
	630.8	634.2	8.40	−9.85	9.76	101.73	97.39	102.50