Rapid-Response and Highly Sensitive Boronate Derivative-Based Fluorescence Probe for Detecting H₂O₂ in Living Cells

Table 1

Comparison of LOD and response time values of present probe with those of boronate-based H₂O₂ sensors recently reported in the literature.

No.	System	Response time (min)	LOD (nM)	References
1	Boronic ester of TPE	∼10	520	[5]
2	Carbon dot featuring boronate recognition unit	30	750	[7]
3	N-4-(Benzyl boronic pinacol ester) pyridinium bromide moiety on TPE	30	180	[8]
4	TPE modified with boronic ester	10	950	[9]
5	Diboronate functionalized TPE	60	3200	[10]
6	Imine derivative of TPE	40	100	[11]
7	Modified hemicyanine dye	90	13	[12]
8	9H-1,3-dichloro-7-hydroxy-9,9-dimethylacridine-2-one	60	420	[13]
9	2-(3-(4-Hydroxystyryl)-5,5-dimethylcyclohex-2-enylidene) malononitrile	30	70	[14]
10	Mitochondria targeted benzothiazole probe	120	23	[15]
11	Phenanthroimidazole, benzonitrile, and phenyl boronate	10	148	[16]
12	4-Carboxy-3-fluorophenylboronic acid and 7-hydroxycoumarin-conjugated probe	60	760	[17]
13	1,3-Bis(bispyridin-2-ylimino)isoindolin-4-ol	40	9.1	[18]
14	Tetrahydroquinoxaline iminocoumarin derivative	10	60	[19]
15	Dioxetane-based probe	—	75000	[20]
16	2-Dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran	60	61	[21]
17	Naphthalimide-coumarin-based ICT-activated FRET sensor	60	1350	[22]
18	Lysosome-targeted two-photon probe	—	1210	[23]
19	Cyanosilbene-boronate-based AIEE probe	—	455	[24]
20	Borylated boron dibenzopyrromethene dye	—	248	[25]
21	Mitochondria-targeted probe	4	40	[26]
22	p-Nitroaniline and 7-amino-4-methyl coumarin bearing probe	8	100	[27]
23	Dicyanomethylene-4-H-chromene	10	450	[28]
24	Dicyanomethylene-4-H-pyran	30	79	[29]
25	4-Hydroxynaphthalimide derivate	40	2000	[30]
26	TPIOP boronate probe in this study	2	8	This work