Research Article

Development and Validation of an HPLC Method for Simultaneous Assay of Potassium Guaiacolsulfonate and Sodium Benzoate in Pediatric Oral Powder

Table 5

Results of accuracy.

Spiked level (%)Replicate numberPotassium guaiacolsulfonateSodium benzoate
Spiked amount of standard (mg)Sum of peaks’ areaRecovery (%)Mean recovery, RSD (%)Spiked amount of standard (mg)Peak areaRecovery (%)Mean recovery, RSD (%)

80123.01988231102.0101.938.41532007101.2101.8
220.61776475101.738.61552884102.0
320.51777035101.90.138.61552844102.00.5

100125.32159862100.7100.348.01918840101.4101.7
225.22199415100.548.21934702101.8
325.4219953899.80.548.21935383101.90.3

120130.62648436100.7100.757.02260622100.6101.0
230.92635143100.657.22283777101.3
330.82634916100.90.257.32284080101.10.4