Development and Validation of an HPLC Method for Simultaneous Assay of Potassium Guaiacolsulfonate and Sodium Benzoate in Pediatric Oral Powder
Table 8
Results of repeatability and intermediate precision.
No. of sample solution
Sample weight (g)
Content of potassium guaiacolsulfonate in oral powder (%, comparing to labeled amount)
Content of sodium benzoate in oral powder (%, comparing to labeled amount)
Day 1, analyst 1
1
0.6152
98.1
101.8
2
0.6224
100.8
100.0
3
0.6369
99.6
101.1
4
0.6102
98.7
102.7
5
0.6224
100.7
99.9
6
0.6394
99.4
100.8
Average (1–6)
99.6
101.0
RSD (%) (1–6)
1.1
1.1
Day 2, analyst 2
7
0.6542
100.3
101.9
8
0.6395
99.2
101.5
9
0.6452
101.3
101.3
10
0.6531
100.4
102.3
11
0.6407
99.0
101.3
12
0.6446
101.6
99.4
Average (1–12)
99.9
101.2
RSD (%) (1–12)
1.1
1.0
Note: results obtained in day 1 by analyst 1 (sample no. 1–6) were used for evaluating repeatability, and those obtained in day 1 and day 2 (sample no. 1–12) were used together for evaluating intermediate precision.
