Functionalized Fe3O4 Magnetic Nanoparticle Potentiometric Detection Strategy versus Classical Potentiometric Strategy for Determination of Chlorpheniramine Maleate and Pseudoephedrine HCl
Table 3
Electrochemical response characteristics of the six investigated membrane sensors.
Parameters
Sensor 1
Sensor 2
Sensor 3
Sensor 4
Sensor 5
Sensor 6
Linearity (mol·L−1)
10−5–10−2
10−5–10−2
10−7–10−2
10−5–10−2
10−6–10−2
10−8–10−2
Correlation coefficient
0.9992
0.9994
0.9996
0.9993
0.9994
0.9995
Slope (mV·decade−1)a
54.6
55.10
58.17
53.70
55.00
57.79
Intercept (mV)a
179.6
167.10
316.77
177.2
154.2
274.79
Average recovery (mean ± SD)a
100.04 ± 0.886
99.89 ± 0.783
99.97 ± 1.068
100.06 ± 0.897
100.12 ± 1.256
100.01 ± 1.026
LOD (mol·L−1)b
8 × 10−6
9.1 × 10−6
5 × 10−8
7 × 10−6
6.9 × 10−6
4 × 10−9
Accuracy (mean ± SD)
101.85 ± 1.258
100.66 ± 1.347
100.98 ± 0.813
101.68 ± 0.985
101.64 ± 1.313
99.45 ± 0.973
Precision (RSD %)
Intraday
1.023
0.998
0.944
1.183
0.994
0.846
Interday
1.155
1.117
0.819
1.063
0.789
0.716
Response time (sec)
10–15
15–20
5–10
10–15
10–15
5–10
Working pH range
4–8
4–8
4–8
4–7
4–7
4–7
Stability (days)
15
20
30
20
25
40
aAverage of five determinations; blimit of detection (measured by interception of the extrapolated arms of Figure 2).
