Functionalized Fe₃O₄ Magnetic Nanoparticle Potentiometric Detection Strategy versus Classical Potentiometric Strategy for Determination of Chlorpheniramine Maleate and Pseudoephedrine HCl

Table 5

Determination of CPM and PSE in pharmaceutical formulation by the proposed sensors and comparison with the reported method.

Pharmaceutical formulation		Sensor 3	Sensor 6	Reported method [23]^b
Sinlerg® tablets labelled to contain 2 mg CPM, 30 mg PSE, and 200 mg IBF/tablet (batch no. 212314)	Mean ± SD^a	102.26 ± 1.204	101.09 ± 1.106	100.63 ± 1.317
	Student’s t test	0.518 (2.26^b)	0.743 (2.26^b)
	F test	1.623 (6.26^b)	1.182 (6.26^b)

^aAverage of five determinations. ^bReported HPLC method using C18 column; flow rate 1.5 mL·min⁻¹; mobile phase is a gradient elution of acetonitrile:buffer (15 : 85, v/v) for 5.5 min, (45 : 55, v/v) for 5.5–12 min, and (60 : 40, v/v) for 12–17 min at pH = 3 and UV detection at 220 nm.