Research Article
Biological Safety Studies and Simultaneous Determination of Linagliptin and Synthetic Impurities by LC-PDA
Figure 4
Results of the biological safety studies of the LGT drug and synthetic impurities in different concentrations. (a) Cellular viability; (b) micronucleus frequency; (c) DNA damage. NC: negative control; PC: positive control; LGT: linagliptin; IMP 1: impurity 1; IMP 2: impurity 2; IMP 3: impurity 3; 10 × Cmax: ten times greater than the maximum concentration of LGT; Cmax: maximum concentration of LGT; Cmax/PP: ten times lower than the maximum concentration of LGT. Different letters differ statistically.
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