Research Article
Biological Safety Studies and Simultaneous Determination of Linagliptin and Synthetic Impurities by LC-PDA
Table 2
Percentage of degradation of LGT under different stress conditions to evaluate the selectivity of the analytical method.
| Exposition time (h) | Conditions evaluated | UVA radiation | 30% (v/v) hydrogen peroxide | Basic thermal (1 mol·L−1 at 80°C) | Acid thermal (1 mol·L−1 at 80°C) | Thermal (80°C) | Acid (1 mol·L−1) | Basic (1 mol·L−1) |
| 0.25 | — | — | 17.14 | — | — | — | — | 0.5 | — | — | 31.26 | — | — | — | — | 0.75 | — | — | 44.24 | — | — | — | — | 1 | 4.36 | — | 58.74 | — | 9.37 | — | — | 1.5 | — | — | 74.14 | — | — | — | — | 2 | 7.75 | 6.87 | 86.57 | 9.04 | 10.00 | — | — | 3 | 13.56 | — | — | — | 8.31 | — | — | 4 | 34.86 | 8.65 | — | 9.89 | — | — | — | 6 | — | 8.73 | — | 11.11 | — | — | — | 10 | — | 9.85 | — | 15.50 | — | — | — | 24 | — | — | — | — | — | 3.12 | 12.06 | 48 | — | — | — | — | — | — | 23.19 |
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