Research Article
Pharmacokinetic Study and Tissue Distribution of Lorlatinib in Mouse Serum and Tissue Samples by Liquid Chromatography-Mass Spectrometry
Table 1
The mass spectrometric parameters of lorlatinib and IS.
| | No. | Compound | Molecular ion (m/z) | Fragmentation ion (m/z) | Cone voltage (V) | Collision energy (V) |
| | 1 | Lorlatinib | 407.28 (quantitative) | 228.09 | 50 | 22 | | 407.28 (qualitative) | 180.08 | 50 | 22 | | 2 | Afatinib-d6 | 492.10 | 371.05 | 58 | 28 |
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