Research Article
Pharmacokinetic Study and Tissue Distribution of Lorlatinib in Mouse Serum and Tissue Samples by Liquid Chromatography-Mass Spectrometry
Table 2
Linearity of calibration curve.
| | Sample | Linear equation | R2 | Linear ranges (ng/mL) |
| | Serum | y = 0.023707 ∗ x + 0.0155831 | 0.997851 | 5.0–1000.00 | | Lung | y = 0.0195495 ∗ x + 0.0138712 | 0.997790 | 5.00–500.00 | | Heart | y = 0.0213465 ∗ x + 0.0092521 | 0.997465 | 5.00–500.00 | | Liver | y = 0.0186958 ∗ x + 0.0147887 | 0.998566 | 5.00–500.00 | | Stomach | y = 0.0204515 ∗ x + 0.0166741 | 0.999105 | 5.00–500.00 | | Spleen | y = 0.0202389 ∗ x + 0.0140355 | 0.995428 | 5.00–500.00 | | Brain | y = 0.0204129 ∗ x + 0.00546792 | 0.999465 | 5.00–500.00 | | Kidney | y = 0.019028 ∗ x + 0.00742472 | 0.999837 | 5.00–500.00 | | Large intestine | y = 0.0210146 ∗ x + 0.00305651 | 0.998751 | 5.00–500.00 | | Small intestine | y = 0.0223395 ∗ x + 0.0109578 | 0.997797 | 5.00–500.00 |
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