Pharmacokinetic Study and Tissue Distribution of Lorlatinib in Mouse Serum and Tissue Samples by Liquid Chromatography-Mass Spectrometry

Table 3

Accuracy and precision for samples (within-day ; between-day ).

Samples	Concentration spiked (ng/ml)	Within-day accuracy (%)	Within-day precision (%)	Between-day accuracy (%)	Between-day precision (%)
Serum	5.00	3.87	2.99	10.17	10.46
	10.00	−1.92	5.04	0.68	7.60
	100.00	2.33	5.01	0.52	7.01
	800.00	2.01	4.06	−0.39	7.18
Lung	5.00	4.83	4.57	0.41	4.86
	10.00	8.35	7.23	6.34	4.82
	100.00	3.62	4.45	3.70	3.38
	400.00	1.96	4.61	2.56	3.36
Heart	5.00	−3.53	6.15	−5.31	5.13
	10.00	7.78	5.51	6.77	4.27
	100.00	6.31	4.79	8.20	5.54
	400.00	5.12	4.70	7.68	4.19
Liver	5.00	1.07	4.07	0.07	7.91
	10.00	4.23	4.77	8.84	7.11
	100.00	6.93	2.50	8.84	4.36
	400.00	4.91	6.14	5.06	4.26
Stomach	5.00	−12.17	5.13	−6.02	8.52
	10.00	0.23	8.24	2.46	5.04
	100.00	1.29	4.01	−0.16	4.03
	400.00	−3.37	3.25	−2.98	3.53
Spleen	5.00	−5.27	6.96	1.22	6.71
	10.00	6.47	2.86	7.94	4.52
	100.00	3.66	7.83	2.74	6.42
	400.00	5.12	3.11	1.21	5.18
Brain	5.00	−1.33	4.04	−0.61	5.12
	10.00	6.50	4.33	0.68	10.38
	100.00	6.07	7.66	0.35	10.98
	400.00	5.50	1.69	−0.42	8.09
Kidney	5.00	−1.73	4.42	−0.82	8.38
	10.00	2.27	3.20	5.91	5.04
	100.00	−3.31	5.43	1.50	5.24
	400.00	−4.68	5.53	1.26	6.64
Large intestine	5.00	−7.47	6.75	−0.94	19.73
	10.00	−0.72	6.82	−3.37	9.60
	100.00	3.20	3.70	−6.42	8.89
	400.00	0.12	2.78	−4.90	8.00
Small intestine	5.00	2.5	5.26	−7.1	9.26
	10.00	3.03	2.38	−0.48	7.79
	100.00	−1.13	3.42	−0.89	3.58
	400.00	−3.43	6.30	−1.78	4.35