Research Article
Pharmacokinetic Study and Tissue Distribution of Lorlatinib in Mouse Serum and Tissue Samples by Liquid Chromatography-Mass Spectrometry
Table 4
Recovery and matrix effect
.
| Samples | Concentration spiked (ng/ml) | Matrix effect (%) | Recovery (%) |
| Serum | 10 | 108.9 | 102.0 | 100 | 110.6 | 103.8 | 800 | 105.7 | 101.4 |
| Lung | 10 | 90.4 | 99.5 | 100 | 85.0 | 103.5 | 500 | 85.3 | 98.5 |
| Heart | 10 | 93.3 | 104.4 | 100 | 88.2 | 101.4 | 500 | 86.8 | 99.1 |
| Liver | 10 | 86.8 | 109.6 | 100 | 88.2 | 102.5 | 500 | 91.1 | 98.1 |
| Stomach | 10 | 91.4 | 110.8 | 100 | 95.5 | 108.3 | 500 | 89.4 | 102.7 |
| Spleen | 10 | 89.0 | 112.1 | 100 | 99.0 | 102.0 | 500 | 91.0 | 108.1 |
| Brain | 10 | 91.3 | 115.0 | 100 | 97.5 | 101.2 | 500 | 96.0 | 91.4 |
| Kidney | 10 | 84.2 | 112.3 | 100 | 89.5 | 107.2 | 500 | 88.7 | 105.5 |
| Large intestine | 10 | 89.4 | 105.4 | 100 | 84.5 | 99.0 | 500 | 84.6 | 103.1 |
| Small intestine | 10 | 97.7 | 93.9 | 100 | 97.0 | 93.2 | 500 | 101.5 | 96.8 |
|
|