Pharmacokinetic Study and Tissue Distribution of Lorlatinib in Mouse Serum and Tissue Samples by Liquid Chromatography-Mass Spectrometry

Table 4

Recovery and matrix effect .

Samples	Concentration spiked (ng/ml)	Matrix effect (%)	Recovery (%)
Serum	10	108.9	102.0
	100	110.6	103.8
	800	105.7	101.4
Lung	10	90.4	99.5
	100	85.0	103.5
	500	85.3	98.5
Heart	10	93.3	104.4
	100	88.2	101.4
	500	86.8	99.1
Liver	10	86.8	109.6
	100	88.2	102.5
	500	91.1	98.1
Stomach	10	91.4	110.8
	100	95.5	108.3
	500	89.4	102.7
Spleen	10	89.0	112.1
	100	99.0	102.0
	500	91.0	108.1
Brain	10	91.3	115.0
	100	97.5	101.2
	500	96.0	91.4
Kidney	10	84.2	112.3
	100	89.5	107.2
	500	88.7	105.5
Large intestine	10	89.4	105.4
	100	84.5	99.0
	500	84.6	103.1
Small intestine	10	97.7	93.9
	100	97.0	93.2
	500	101.5	96.8