Pharmacokinetic Study and Tissue Distribution of Lorlatinib in Mouse Serum and Tissue Samples by Liquid Chromatography-Mass Spectrometry

Table 5

Pharmacokinetic parameters of lorlatinib in mice after oral administration at a dose of 10 mg/kg .

Parameters	Unit	Mean	SD	RSD (%)
AUC(0–∞)	ug/L ∗ h	16208.177	1720.36	10.61
AUMC(0–∞)	h ∗ h ∗ ug/L	78840.738	10257.22	13.01
t1/2z	h	3.261	0.168	5.17
Tmax	h	0.625	0.231	37.03
Cmax	ug/L	2705.683	539.779	19.95