Research Article
The Application of CA and PCA to the Evaluation of Lipophilicity and Physicochemical Properties of Tetracyclic Diazaphenothiazine Derivatives
Table 1
Values of log Plit parameters, experimentally determined RM0, and log PTLC for reference substances I–V.
| Lipophilicity | Standard substances | I [42] | II [43] | III [44] | IV [42] | V [44] |
| log Plit | 1.2100 | 1.9700 | 2.4300 | 3.1800 | 4.4500 | R M0 | 0.6800 | 1.2930 | 1.6260 | 2.2240 | 2.8500 | −b | 0.0119 | 0.0196 | 0.0207 | 0.0280 | 0.0335 | r | 0.9908 | 0.9953 | 0.9945 | 0.9985 | 0.9989 | SD | 0.0296 | 0.0346 | 0.0398 | 0.0278 | 0.0282 | log PTLC | 1.0670 | 2.0380 | 2.5090 | 3.3630 | 4.2610 |
|
|
b: slope; r: correlation coefficient; SD: standard error.
|