A Sensitive and Efficient Method for Determination of Capecitabine and Its Five Metabolites in Human Plasma Based on One-Step Liquid-Liquid Extraction

Figure 3

Representative MRM chromatograms of Cap and its five metabolites. (a) Blank sample; (b) blank sample spiked IS; (c) blank sample spiked with LLOQ concentration of Cap and its metabolites; (d) real sample collected from one colorectal cancer patient after administration of Cap.

(a)

(b)

(c)

(d)