Simultaneous Determination of 34 Amino Acids in Tumor Tissues from Colorectal Cancer Patients Based on the Targeted UHPLC-MS/MS Method

Table 5

The median and SD values of 34 amino acids in cancerous, paracancerous, and normal tissue from 94 CRC patients.

Analyte	Cancerous tissue (μg/g)		Paracancerous tissue (μg/g)		Normal tissue (μg/g)
	Median	SD	Median	SD	Median	SD
Gly	244.454	110.611	156.906	91.526	141.401	79.605
Ala	330.693	163.616	244.684	145.235	177.389	137.482
Ser	143.072	92.541	124.721	84.070	109.057	78.118
Val	141.541	58.259	107.203	56.744	102.171	54.720
Thr	104.922	63.748	73.603	59.520	67.197	54.334
Leu	181.020	94.785	122.750	84.062	118.304	79.573
Ile	97.020	58.074	71.391	43.525	70.712	41.863
Asp	107.197	67.386	69.694	44.618	70.323	42.289
Lys	284.995	231.061	278.033	248.794	255.968	217.480
Gln	159.779	77.801	170.369	70.657	173.578	64.244
Glu	335.986	145.846	268.418	116.329	264.143	100.596
Phe	127.176	70.195	85.905	58.385	84.676	57.804
Arg	150.227	97.943	127.102	79.598	119.700	72.975
Tyr	113.370	60.918	88.310	47.617	87.389	46.861
Pro	141.950	152.552	68.731	110.943	65.552	99.701
Asn	54.833	42.362	42.362	28.168	39.203	25.920
Met	76.329	45.541	63.348	31.676	61.494	32.014
Trp	32.690	19.826	27.032	17.460	23.207	17.925
Cys	15.593	16.903	10.482	6.979	9.233	6.233
His	6.044	5.366	4.033	4.267	3.050	4.008
Cit	16.222	16.414	16.281	14.671	17.802	13.330
ADMA	17.082	11.799	7.841	9.571	6.117	8.310
Cyss	26.370	33.970	10.720	14.34	6.713	11.742
Sar	0.611	0.490	0.520	0.384	0.491	0.281
Apa	1.934	1.456	0.529	0.266	0.474	0.192
Amp	0.525	0.474	0.469	0.284	0.478	0.286
Aba	2.341	2.356	2.069	1.857	1.246	1.745
Opr	2.982	3.705	2.637	2.047	2.514	1.955
Hpr	2.390	1.385	1.425	0.831	1.282	0.791
Orn	1.551	2.266	1.043	1.634	1.101	1.735
Ahd	0.481	0.390	0.745	0.514	0.862	0.458
Hia	0.656	0.103	0.546	0.220	0.625	0.358
SDMA	1.525	1.093	1.116	1.139	1.145	1.017
Kyn	7.065	8.108	2.043	1.553	1.536	1.488