Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract

Table 3

Precision and accuracy for monotropein, rubiadin, and rubiadin 1-methyl ether in biological samples.

Matrix	Compounds	Conc. (μg/mL)	Intra-day (n = 5)		Inter-day (n = 5)
			Precision (RSD%)	Accuracy (RE%)	Precision (RSD%)	Accuracy (RE%)
Plasma	Rubiadin	3.6	1.23	−8.06	0.21	−3.06
		50.6	2.77	−2.92	2.85	−2.75
		712.5	5.96	−2.01	2.79	−4.15
	Rubiadin 1-methyl ether	3.9	4.91	−7.44	3.42	−2.82
		54.6	2.33	−0.33	1.73	−2.44
		765	2.28	−5.45	3.33	−3.53
	Monotropein	0.14	3.51	−1.42	3.27	−2.13
		2	1.25	−3.4	1.93	−0.9
		28.1	2.79	−3.36	0.76	−2.9
Small intestine	Rubiadin	0.21	4.44	−1.43	4.75	−2.86
		0.98	4.43	−0.1	4.62	1.12
		4.63	4.55	−0.41	1.15	−0.82
	Rubiadin 1-methyl ether	0.15	1.66	−0.67	1.12	−2.67
		0.72	5.83	−0.69	5.05	0.14
		3.49	5.55	−0.14	2.85	0.06
	Monotropein	1.41	5.55	−0.07	1.72	−0.71
		6.2	1.63	−1.29	2.48	0.16
		28.13	3.49	−0.64	3.41	−0.25
Liver	Rubiadin	0.21	3.43	−0.48	1.9	−0.48
		0.98	1.3	−0.51	2.89	−0.41
		4.63	2.5	−0.13	3.33	0.04
	Rubiadin 1-methyl ether	0.15	2.42	−4	4.62	1.33
		0.72	1.57	−0.28	5.56	−1.25
		3.49	2.27	−0.11	2.54	−0.2
	Monotropein	1.41	4.36	−0.35	4.75	−0.78
		6.2	1.32	−0.81	2.2	0.48
		28.13	5.95	−2.03	3.82	0.03
Kidney	Rubiadin	0.21	1.86	−0.05	5.96	−3.81
		0.98	1.56	−0.51	3.71	−0.51
		4.63	3.23	−0.11	2.36	−0.13
	Rubiadin 1-methyl ether	0.15	3.33	−2	4.18	−2.67
		0.72	3.06	−0.56	4.35	−0.28
		3.49	2.17	−0.14	4.35	0.09
	Monotropein	1.41	1.5	−0.78	2.54	−0.64
		6.2	3.74	−1.29	3.5	−0.81
		28.13	1.21	0.02	3.63	−0.5
Lung	Rubiadin	0.21	1.2	−0.38	2.15	0.48
		0.98	2.88	−0.51	1.8	0.2
		4.63	5.93	−0.04	3.33	−0.17
	Rubiadin 1-methyl ether	0.15	5.04	−2.67	0.6	−1.33
		0.72	1.33	−0.28	1.59	0.28
		3.49	5.52	−0.06	1.72	0.06