Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract

Table 4

Stability of the three components in rat plasma and tissues (n = 5).

Matrix	Compounds	Conc (μg/mL)	At 25°C for 12 h		−20°C for 30 days		Autosampler at 4°C for 24 h		Freeze–thaw cycles
				RSD%		RSD		RSD		RSD
			RE%		RE%	%	RE%	%	RE%	%
Plasma	Rubiadin	3.6	−6.23	4.18	−3.16	2.13	−1.72	3.13	−0.92	4.22
		50.6	−1.62	3.86	−2.38	1.45	−0.97	4.13	−1.35	1.45
		712.5	−4.1	4.41	−2.46	3.81	−1.76	3.56	−2.34	6.27
	Rubiadin 1-methyl ether	3.9	−1.79	1.63	−3.26	2.36	−1.49	2.48	−0.94	3.85
		54.6	−4.21	3.41	−0.23	3.42	−1.65	3.53	−1.35	3.18
		765	−5.1	2.81	−0.86	3.13	−3.14	1.73	−3.71	2.45
	Monotropein	0.14	−0.14	3.21	−1.21	2.51	−2.39	2.46	−1.95	2.99
		2	−0.13	2.41	−0.24	2.91	−0.46	3.74	−0.52	4.82
		28.1	−0.21	3.92	−1.36	4.82	−1.23	3.69	−2.89	3.91
Small intestine	Rubiadin	0.21	−0.07	2.59	−0.35	1.98	−0.64	5.7	−0.45	3.54
		0.98	−0.57	2.96	−2.71	1.14	−1.65	5.79	−0.38	3.85
		4.63	−1.47	5.43	−0.87	8.51	−1.67	2.97	0.39	2.68
	Rubiadin 1-methyl ether	0.15	−0.69	7.53	−1.25	0.65	−0.42	2.74	−6.57	8.41
		0.72	−0.85	6.41	−0.25	4.23	−0.62	2.19	−0.57	1.88
		3.49	0.25	2.47	1.35	2.49	0.48	7.29	−0.74	8.82
	Monotropein	1.41	−0.63	3.61	−0.85	1.58	−0.35	4.86	−0.99	1.25
		6.2	−1.41	5.93	−0.71	3.87	−0.66	5.87	0.15	6.02
		28.13	−2.27	4.86	−0.12	4.64	−0.01	6.84	−0.01	2.57
Liver	Rubiadin	0.21	−0.52	1.38	−0.54	1.28	0.26	1.07	−5.57	6.37
		0.98	−2.43	0.86	−0.8	8.16	−0.33	2.08	0.25	4.23
		4.63	−0.57	2.36	1.57	5.37	−2.36	2.97	0.27	3.67
	Rubiadin 1-methyl ether	0.15	−2.1	5.64	−0.58	3.76	0.54	2.97	−1.52	5.24
		0.72	−3.42	6.84	−0.45	1.53	−3.81	7.23	−5.42	4.27
		3.49	0.42	2.23	−2.58	2.45	−0.66	3.88	−0.68	2.68
	Monotropein	1.41	−0.85	0.41	−1.84	6.21	−2.98	1.78	−1.77	3.72
		6.2	0.56	1.68	−0.52	4.2	0.23	2.87	−0.84	2.98
		28.13	−1.71	3.69	−0.65	3.51	−3.16	2.97	0.09	1.96
Kidney	Rubiadin	0.21	−0.42	0.32	−0.54	6.45	−0.45	7.95	−0.57	1.87
		0.98	−0.38	0.98	−2.45	2.76	−6.72	4.56	−1.57	6.41
		4.63	−0.17	3.76	−0.67	0.64	1.46	2.17	0.38	5.13
	Rubiadin 1-methyl ether	0.15	0.35	2.94	−5.1	2.76	−0.36	1.56	0.15	2.51
		0.72	0.24	1.9	−2.49	3.57	−0.68	2.35	−0.54	5.42
		3.49	−3.58	4.35	0.54	1.94	−0.36	3.56	−1.57	4.23
	Monotropein	1.41	−0.28	6.72	−0.86	1.62	−0.18	3.5	0.24	3.69
		6.2	−0.67	6.42	−0.46	7.56	−0.57	5.44	0.07	4.29
		28.13	−0.68	0.34	−0.27	6.52	0.25	2.34	−0.57	2.86
Lung	Rubiadin	0.21	0.65	0.86	0.42	3.87	−0.24	5.44	−0.38	5.71
		0.98	0.38	3.57	0.48	0.68	−0.54	3.46	−1.57	5.74
		4.63	0.68	6.84	−5.71	0.42	−0.57	3.55	0.35	6.7
	Rubiadin 1-methyl ether	0.15	−0.57	6.42	−1.54	0.35	−8.51	7.62	−2.57	3.85
		0.72	−5.71	2.43	−0.55	7.36	−0.65	3.57	−4.85	4.42
		3.49	−0.06	2.46	0.05	4.51	−2.42	6.58	−0.53	2.46