Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract

Table 6

Pharmacokinetic parameters of the three components in rat plasma (n = 6).

Parameters	Units	Mean (rubiadin)		Mean (rubiadin 1-methyl ether)		Mean (monotropein)
		MO	SMO	MO	SMO	MO	SMO
AUC (0-t)	μg/L  h	152.252 ± 7.098	169.355 ± 8.836	1059.49 ± 98.081	1244.329 ± 82.805	44.22 ± 0.932	26.941 ± 1.423
AUC (0-∞)	μg/L  h	153.816 ± 7.169	176.441 ± 18.283	1074.351 ± 102.019	1253.526 ± 84.691	48.952 ± 1.559	27.045 ± 1.338
MRT (0-t)	H	6.062 ± 0.272	5.89 ± 0.265	2.908 ± 0.151	2.855 ± 0.15	3.863 ± 0.184	1.686 ± 0.025
t1/2z	H	3.838 ± 0.196	5.006 ± 3.383	5.379 ± 1.514	4.27 ± 0.865	12.291 ± 2.09	5.611 ± 3.958
Tmax	H	1.5 ± 0.00	1.5 ± 0.00	0.5 ± 0.00	0.5 ± 0.00	1.0 ± 0.00	0.5 ± 0.00
Cmax	μg/L	46.667 ± 12.941	50.2 ± 8.903	432.367 ± 37.012	509 ± 35.133	23.298 ± 0.764	23.253 ± 0.676
V/F	L/g	1.442 ± 0.090	1.579 ± 0.842	0.287 ± 0.067	0.196 ± 0.363	14.447 ± 2.143	12.239 ± 9.027
CL/F	L/g·h	0.261 ± 0.012	0.228 ± 0.022	0.037 ± 0.372	0.032 ± 0.210	0.818 ± 0.265	1.482 ± 0.750