Research Article
An Analytical Perspective on Determination of Free Base Nicotine in E-Liquids
Table 4
Determination of free base nicotine in e-liquid samples by toluene-water double extraction.
| e-Liquid flavor | e-Liquid category | pH of 10x dilution in water (0.8 mg/mL) | % free base nicotine by Henderson–Hasselbalch equation | Experimental % free base nicotine | % difference | Mean % difference | Std. dev. |
| Maui menthol | Menthol | 8.51 | 68.68 | 65.00 | 5.36 | 5.74 | 4.58 | 67.74 | 1.37 | 61.47 | 10.50 |
| Element tobacco | Tobacco | 8.01 | 41.00 | 73.25 | 78.64 | 76.90 | 3.48 | 73.46 | 79.16 | 70.89 | 72.89 |
| Motley brew | Fruit | 7.82 | 30.93 | 80.71 | 160.98 | 160.28 | 1.04 | 80.65 | 160.78 | 80.12 | 159.08 |
| Milkman milky cloud | Sweet | 7.57 | 19.93 | 76.02 | 281.48 | 277.02 | 3.89 | 74.61 | 274.38 | 74.77 | 275.18 |
| Hazelnut coffee | Coffee | 8.82 | 81.81 | 88.79 | 8.53 | 8.76 | 0.20 | 89.04 | 8.84 | 89.10 | 8.91 |
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