An Analytical Perspective on Determination of Free Base Nicotine in E-Liquids

Table 5

Determination of free base nicotine in e-liquids by ¹H NMR spectroscopy (e-liquids without dilution).

e-Liquid flavor (80 mg/mL)	e-Liquid category	% experimental free base nicotine	Mean % free base nicotine	Standard deviation
Maui menthol	Menthol	71.56	69.41	1.87
		68.34
		68.32
Element tobacco	Tobacco	74.83	73.60	1.07
		73.01
		72.95
Motley brew	Fruit	75.87	74.40	1.27
		73.64
		73.70
Milkman milky cloud	Sweet	75.79	75.80	0.02
		75.81
		75.79
Hazelnut coffee	Coffee	91.76	92.88	0.97
		93.48
		93.40