Research Article
Development and Validation of LC-MS/MS for Analyzing Potential Genotoxic Impurities in Pantoprazole Starting Materials
Table 1
Mass spectrometric conditions for the LC-MS/MS analysis of impurities C–H.
| Compound | Precursor ion m/z | Product ion m/z | Fragmentor (V) | CE (eV) | EMV (+) | MS1 RES | MS2 RES |
| DMBZ | 217.1 | 166.9 | 135 | 30 | 500 | Wide | Unit | Impurity C | 160.2 | 93.0 | 115 | 20 | 500 | Wide | Unit | Impurity D | 202.2 | 160.0 | 115 | 15 | 500 | Wide | Unit | Impurity E | 175.1 | 108.0 | 115 | 20 | 500 | Wide | Unit | Impurity F | 247.1 | 187.0 | 125 | 15 | 500 | Wide | Unit | Impurity G | 205.1 | 137.0 | 115 | 15 | 500 | Wide | Unit | Impurity H | 110.1 | 65.0 | 135 | 20 | 500 | Wide | Unit |
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