Development and Validation of LC-MS/MS for Analyzing Potential Genotoxic Impurities in Pantoprazole Starting Materials

Table 4

Amount of impurities C–H in starting material DMBZ.

PGIs (ng/mL)	Batch no
	20130323	20130519	20141001	20180903	20181001	20181003
Impurity C	1.54	0.50	0.50	0.02	0.04	0.05
Impurity D	0.49	0.19	0.19	0.02	0.07	0.05
Impurity E	0.04	0.03	0.27	0.67	0.36	0.61
Impurity F	0.17	0.24	0.02	0.01	0.01	0.01
Impurity G	0.60	0.09	0.09	0.02	0.04	0.01
Impurity H	0.12	0.07	0.07	0.01	0.01	0.01

The calculated value is lower than the LOQ, for reference only.