RP-HPLC and UV Spectrophotometric Analysis of Paracetamol, Ibuprofen, and Caffeine in Solid Pharmaceutical Dosage Forms by Derivative, Fourier, and Wavelet Transforms: A Comparison Study

Table 2

Assay results for the determination of PA, IB, and CA in solid pharmaceutical dosage forms.

% Of label claim (mean ± SD, n = 6)
Method	Bidi-Ipalvic			Ibu-Acetalvic			Glotasic
	PA	IB	CA	PA	IB	CA	PA	IB	CA
RP-HPLC	100.9 ± 1.9	100.4 ± 2.0	100.5 ± 1.9	101.2 ± 1.9	100.6 ± 2.5	102.5 ± 1.9	101.6 ± 2.5	100.1 ± 2.6	100.9 ± 2.7
Derivative transform
Single divisor	100.0 ± 1.7	99.9 ± 2.1	100.9 ± 1.9	99.9 ± 2.1	98.5 ± 2.6	102.7 ± 2.6	100.9 ± 2.4	98.8 ± 2.7	100.5 ± 1.8
Double divisor	101.3 ± 2.5	99.7 ± 2.4	101.1 ± 1.7	101.1 ± 2.4	101.1 ± 2.4	99.7 ± 2.7	100.6 ± 2.6	100.3 ± 1.9	100.9 ± 1.9
Successive divisor	100.4 ± 1.7	99.6 ± 2.1	100.2 ± 2.3	100.9 ± 2.4	101.7 ± 1.9	101.1 ± 2.5	101.9 ± 2.4	100.6 ± 2.5	99.2 + 2.6
Fourier transform
Double divisor	100.7 ± 2.1	—	—	99.9 ± 2.5	—	—	100.4 ± 2.4	—	—
Wavelet transform
Single divisor	101.3 ± 1.5	100.0 ± 1.4	100.6 ± 1.6	99.6 ± 2.0	101.2 ± 2.5	99.9 ± 2.3	98.8 ± 2.0	100.2 ± 2.1	100.8 ± 2.1
Double divisor	100.1 ± 2.0	100.4 ± 1.8	—	101.9 ± 2.6	99.4 ± 2.3	—	100.6 ± 2.0	100.3 ± 2.2	—
Successive divisor	101.5 ± 2.1	100.7 ± 1.8	100.2 ± 2.4	101.5 ± 2.5	99.9 ± 2.4	99.4 ± 2.5	99.2 ± 2.2	101.2 ± 2.0	101.2 ± 2.5