Development of a Simple and Powerful Analytical Method for Formaldehyde Detection and Quantitation in Blood Samples

Table 3

Overview of the parameters for the analysis of FA in blood.

Order	Blood sample	Analytical system		Detection limits	Pretreatment				Reference
	Source	Separation	Detection	(pg μL^–1)	Stabilization	Derivatizer	Others	Dilution factor
1	Yucatan minipig	HPLC	UV	0.251 (LOD)	○ (using K3EDTA)	DNPH	– Vortexing (2 min)	35	This study
2	SD rat	HPLC	MS/MS	1.5	○ (using K3EDTA)	DNPH	– Vortexing (above 3 min); – Room temp. Reaction (15 min)	91	Kleinnijenguis et al. [17]
3	Human (blood plasma)	HPLC	FL	460 (LOD)	×	Ampicillin	– Vortexing (1.5 min); – Heating (1 ); – Cooling; – Rinsing; – Centrifugation (5 min); – Drying	Above 24.3	Luo et al. [36]
4	Fischer-344 rat	GC	MS	Not available	×	PFPH	– Incubation (2 h); – Extraction	Above 9.71	Heck et al. [35]

DNPH: 2,4-dinitrophenylhydrazine; FL: fluorescence; GC: gas chromatography; HPLC: high-performance liquid chromatography; LOD: limit of detection; MS: mass spectrometry; PFPH: pentafluorophenylhydrazine; SD rat: Spragure–Dawley rat.