Simultaneous Determination of Five Components of Chaihu-Shugan-San in Beagle Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study after a Single Dose of Chaihu-Shugan-San

Table 4

The specific concentration of calibration curve standards and QC samples.

Analyte	Concentration range of calibration standards (ng/mL)	Concentration of QC samples (ng/mL)
		Low	Medium	High
Neohesperidin	0.5, 1, 2.5, 5, 10, 25, 50, 100	1	25	75
Hesperidin	0.5, 1, 2.5, 5, 10, 25, 50, 100	1	25	75
Naringin	1, 2.5, 5, 10, 25, 50, 100, 200	2.5	50	150
Paeoniflorin	1, 2.5, 5, 10, 25, 50, 100, 200	2.5	50	150
Liquiritin	1, 2.5, 5, 10, 25, 50, 100, 200	2.5	50	150