Simultaneous Determination of Five Components of Chaihu-Shugan-San in Beagle Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study after a Single Dose of Chaihu-Shugan-San

Table 7

Main pharmacokinetic parameters of five analytes after giving a single dose of CHSGS (n = 6).

Parameters	Neohesperidin	Hesperidin	Naringin	Paeoniflorin	Liquiritin
t1/2 (h)	0.69 ± 0.17	0.71 ± 0.18	0.97 ± 0.12	0.75 ± 0.34	0.55 ± 0.06
Tmax (h)	1.58 ± 0.38	1.75 ± 0.27	0.92 ± 0.13	2.67 ± 0.52	3.00 ± 0.00
MRT(0−t) (h)	1.88 ± 0.12	1.95 ± 0.12	1.92 ± 0.08	2.94 ± 0.18	2.91 ± 0.07
MRT(0−∞) (h)	1.93 ± 0.13	2.00 ± 0.15	2.07 ± 0.17	2.97 ± 0.17	2.95 ± 0.07
Cmax (ng/mL)	31.22 ± 2.52	36.53 ± 5.44	67.92 ± 3.00	111.24 ± 17.77	45.00 ± 7.90
AUC(0−t) (ng·h/mL)	75.48 ± 7.00	75.01 ± 9.91	150.21 ± 15.18	282.07 ± 69.49	85.37 ± 18.81
AUC(0−∞) (ng·h/mL)	76.29 ± 7.27	76.04 ± 10.35	154.02 ± 16.40	297.87 ± 93.01	86.70 ± 19.04