Research Article
Development and Application of a LC-MS/MS Method for Simultaneous Quantification of Four First-Line Antituberculosis Drugs in Human Serum
Table 2
Regression equation, correlation coefficient, linearity range, and LLOQ of each analyte.
| | Analytes | Regression equation | Correlation coefficient (r) | Linearity range (μg/mL) | LLOQ (μg/mL) |
| | PZA | YPZA = (0.2423 ± 0.0006) x + (0.0230 ± 0.0046) | 0.9992 ± 0.0004 | 1.02∼60.0 | 1.02 | | INH | YINH = (0.6607 ± 0.0323) x + (0.0090 ± 0.0071) | 0.9991 ± 0.0004 | 0.152∼10.0 | 0.152 | | EMB | YEMB = (0.3503 ± 0.0012) x + (0.0027 ± 0.0015) | 0.9995 ± 0.0003 | 0.0998∼5.99 | 0.0998 | | RFP | YRFP = (0.1839 ± 0.1354) x + (0.0185 ± 0.0046) | 0.9982 ± 0.0020 | 0.500∼30.0 | 0.500 |
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PZA: pyrazinamide, INH: isoniazid, RFP: rifampicin, EMB: ethambutol, and LLOQ: lower limit of qualification.
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