Simultaneous Determination of Multiple Active Components from Bushen Pills and Application in a Pharmacokinetic Study in Rats

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Parameters</td><td class="align_center">PF</td><td class="align_center">BBR</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left"><i>T</i><sub>max</sub> (h)</td><td class="align_center">2.60 ± 0.55</td><td class="align_center">0.90 ± 0.14</td></tr><tr><td class="align_left"><i>C</i><sub>max</sub> (ng/mL)</td><td class="align_center">692.56 ± 104.95</td><td class="align_center">6.18 ± 1.89</td></tr><tr><td class="align_left"><i>t</i><sub>1/2</sub> (h)</td><td class="align_center">3.64 ± 1.87</td><td class="align_center">9.59 ± 4.25</td></tr><tr><td class="align_left">AUC<sub>0–24</sub> (ng/mL·h)</td><td class="align_center">2675.39 ± 465.63</td><td class="align_center">9.23 ± 1.78</td></tr><tr><td class="align_left">AUC<sub>0–∞</sub> (ng/mL·h)</td><td class="align_center">2732.27 ± 467.85</td><td class="align_center">10.98 ± 2.45</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>The main pharmacokinetic parameters of PF and BBR after dosing with BSPs in rats (mean ± SD, <i>n</i> = 5).</div>

Journal of Analytical Methods in Chemistry

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Table 3

Table 3: Simultaneous Determination of Multiple Active Components from Bushen Pills and Application in a Pharmacokinetic Study in Rats 