LC-MS/MS Method for Rapid Quantification of Progesterone in Rabbit Plasma and Its Application in a Pharmacokinetic Study of the Transdermal Formulation

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Parameter</td><td class="align_center">Eutectic-hydrogel system (±SD)</td><td class="align_center">Reference drug formulation (±SD)</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left"><i>C</i><sub>max</sub> (ng/mL)</td><td class="align_center">11.1 ± 0.66</td><td class="align_center">8.49 ± 3.32</td></tr><tr><td class="align_left"><i>T</i><sub>max</sub> (h)</td><td class="align_center">6.67 ± 0.58</td><td class="align_center">6.33 ± 0.58</td></tr><tr><td class="align_left">AUC<sub>0−10 h</sub> (ng.h/mL)</td><td class="align_center">69.0 ± 6.49</td><td class="align_center">46.5 ± 21.9</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Pharmacokinetic parameters of progesterone on rabbit models.</div>

Journal of Analytical Methods in Chemistry

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Table 3

Table 3: LC-MS/MS Method for Rapid Quantification of Progesterone in Rabbit Plasma and Its Application in a Pharmacokinetic Study of the Transdermal Formulation 

Table 3 | LC-MS/MS Method for Rapid Quantification of Progesterone in Rabbit Plasma and Its Application in a Pharmacokinetic Study of the Transdermal Formulation 