Research Article
Pharmacokinetic and Lipidomic Assessment of the In Vivo Effects of Parishin A-Isorhynchophylline in Rat Migraine Models
Table 2
Identification of important potential serum lipidomic biomarkers in migraine model rats.
| | No. | Lipid biomarkers | Ion mode | M.F | Mass (M/z) | Rt (min) | FC (control/model) | value | VIP | AUC | | 1 h; 24 h | 1 h; 24 h | 1 h; 24 h | 1 h;24 h |
| | 1 | PC (8 : 0e/10 : 0) | [M + HCOO]− | C27 H55 O9 N1 P1 | 568.3620 | 4.60 | 0.18; 0.11 | 4.37E − 04; 1.12E − 04 | 10.848; 9.945 | 0.88; 0.88 | | 2 | PC (25 : 0/9 : 0) | [M + HCOO]− | C43 H85 O10 N1 P1 | 806.5917 | 13.04 | 0.57; 0.59 | 9.82E − 03; 1.51E − 02 | 3.330; 2.141 | 0.89; 0.81 | | 3 | PC (20 : 1/14 : 0) | [M + HCOO]− | C43 H83 O10 N1 P1 | 804.5760 | 11.49 | 0.51; 0.41 | 1.96E − 04; 2.12E − 02 | 1.937; 1.369 | 1.00; 0.78 | | 4 | PC (13 : 0/23 : 4) | [M + HCOO]− | C45 H81 O10 N1 P1 | 826.5604 | 9.80 | 0.58; 0.58 | 3.34E − 02; 2.94E − 03 | 8.614; 6.792 | 0.86; 0.91 | | 5 | PC (17 : 0/21 : 4) | [M + HCOO]− | C47 H85 O10 N1 P1 | 854.5917 | 11.74 | 0.55; 0.53 | 3.20E − 03; 4.64E − 03 | 3.534; 2.470 | 0.88; 0.89 | | 6 | PC (21 : 4/17 : 2) | [M + HCOO]− | C47 H81 O10 N1 P1 | 850.5604 | 9.34 | 0.15; 0.11 | 2.19E − 06; 9.69E − 05 | 8.038; 6.412 | 1.00; 0.88 | | 7 | PC (28 : 4/12 : 0) | [M + HCOO]− | C49 H89 O10 N1 P1 | 882.6230 | 12.88 | 0.33; 0.15 | 9.93E − 03; 2.53E − 06 | 1.265; 1.736 | 0.83; 1.00 | | 8 | PC (18 : 0/18 : 2) | [M + H]+ | C44 H85 O8 N1 P1 | 786.6007 | 11.94 | 0.5; 0.27 | 9.35E − 03; 9.98E − 05 | 3.445; 5.129 | 0.92; 1.00 | | 9 | PC (18 : 0/20 : 4) | [M + H]+ | C46 H85 O8 N1 P1 | 810.6007 | 11.77 | 0.62; 0.4 | 2.30E − 02; 9.21E − 06 | 2.354; 3.620 | 0.84; 0.98 | | 10 | PC (20 : 3/20 : 3) | [M + H]+ | C48 H85 O8 N1 P1 | 834.6007 | 11.08 | 0.25; 0.13 | 4.73E − 03; 1.11E − 03 | 4.455; 5.632 | 0.80; 0.77 | | 11 | LPC (16 : 0) | [M + H]+ | C24 H51 O7 N1 P1 | 496.3398 | 4.02 | 0.39; 0.12 | 4.48E − 03; 1.15E − 04 | 1.101; 2.053 | 0.88; 1.00 | | 12 | LPE (16 : 0) | [M − H]− | C23 H47 O7 N1 P1 | 480.3096 | 2.98 | 0.64; 0.55 | 1.43E − 02; 2.29E − 03 | 6.555; 5.865 | 0.89; 0.92 | | 13 | SM (d25 : 0/16 : 1) | [M + HCOO]− | C47 H94 O8 N2 P1 | 845.6753 | 15.50 | 0.36; 0.18 | 2.59E − 02; 2.22E − 02 | 1.880; 2.112 | 0.81; 0.75 | | 14 | SM (d17 : 0/24 : 2) | [M + CH3COO]− | C48 H94 O8 N2 P1 | 813.6844 | 14.42 | 0.03; 0.01 | 2.90E − 04; 2.28E − 03 | 2.678; 3.152 | 1.00; 0.98 | | 15 | SM (d16 : 0/26 : 2) | [M + H]+ | C47 H94 O6 N2 P1 | 857.6753 | 13.97 | 0.03; 0.01 | 1.27E − 02; 3.49E − 04 | 1.768; 2.711 | 0.97; 0.95 | | 16 | CerG2 (d13 : 0/19 : 1) | [M + H]+ | C44 H84 O13 N1 | 834.5937 | 11.08 | 0.32; 0.18 | 1.54E − 03; 1.98E − 03 | 4.688; 5.277 | 0.88; 0.77 |
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