Metabolite Profiling of Meridianin C In Vivo of Rat by UHPLC/Q-TOF MS

Table 3

Relative content of 14 metabolites of MC in rat plasma, bile, urine, and feces.

Metabolite	Metabolic pathway	Relative content (%)
		Plasma	Bile	Urine	Feces
M1	Hydroxylation + glucuronide conjugation	1.4	45.5	29.2	0.3
M2	Hydroxylation + sulfation	6.5	28.2	29.7	1.0
M3	Hydroxylation	0.3	0.0	8.3	11.9
M4	Glucuronide conjugation	2.9	4.3	0.9	5.0
M5	Glucuronide conjugation	4.9	1.8	0.6	2.4
M6	Hydroxylation	0.0	0.0	0.0	4.2
M7	Glucuronide conjugation	0.0	0.0	1.5	0.2
M8	2x Hydroxylation	0.3	0.0	1.3	0.2
M9	Hydroxylation + glucuronide conjugation	0.6	6.0	12.5	1.6
M10	Parent	75.8	11.7	9.1	57.7
M11	Hydroxylation + sulfation	3.1	2.7	6.9	12.0
M12	Hydroxylation	0.0	0.3	0.0	3.1
M13	3x Hydroxylation	0.0	0.0	0.0	0.3
M14	Hydration + glucuronide conjugation + 2× alcohols dehydration	4.2	0.0	0.0	0.2