Development and Validation of Ecofriendly HPLC-MS Method for Quantitative Assay of Amoxicillin, Dicloxacillin, and Their Official Impurity in Pure and Dosage Forms

Table 3

Penalty points of the reported HPLC method and the proposed HPLC-MS method.

Reagent/Instrument	Penalty points
	Reported HPLC [33]	Proposed HPLC-MS
Acetonitrile	20	20
Acetic acid	4	0
Energy	0	2
Waste	5	3
Occupational hazards	0	0
Total penalty points	Σ 29	Σ 25
Analytical eco-scale total score	71	75