Sensitive Quantification of Liensinine Alkaloid Using a HPLC-MS/MS Method and Its Application in Microvolume Rat Plasma

Figure 5

Representative MRM chromatograms of the liensinine and dauricine (IS) in rat plasma samples. (a) A blank plasma sample. (b) blank plasma sample spiked with liensinine in LLOQ and IS (20 ng/mL). (c), (d), (e) A rat plasma sample taken 3 h after oral administration of liensinine 5.0 mg/kg, 12.5 mg/kg, 25.0 mg/kg in rats; (1) liensinine and (2) dauricine (IS) (20 ng/mL).

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