Sensitive Quantification of Liensinine Alkaloid Using a HPLC-MS/MS Method and Its Application in Microvolume Rat Plasma

Table 7

Results of the main pharmacokinetic parameters of liensinine after intragastric administration of liensinine (5 mg/kg) to rats.

Pharmacokinetic parameters	Mean ± SD (n = 5)
	Intragastric	Intravenous
AUC0-t (ng h/ml)	60.97 ± 6.91	1164.09 ± 322.26
AUC0-∞ (ng h/ml)	81.92 ± 22.79	1369.09 ± 319.15
T1/2 (h)	12.72 ± 6.61	9.81 ± 2.39
MRT (h)	16.95 ± 7.3	11.70 ± 2.42
V (L/Kg)	64.42 ± 15.84	56.20 ± 24.81
CL (L/h/Kg)	3.89 ± 1.12	3.82 ± 0.91
Cmax (ng/ml)	6.70 ± 1.32	668.4 ± 157.9