Pharmacokinetics of 10-Hydroxy Mesaconitine in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Quadrupole Mass Spectrometry

Table 3

Main pharmacokinetic parameters of 10-hydroxy mesaconitine in rats.

Parameters	Unit	iv 0.1 mg/kg	po 5 mg/kg
AUC(0 − t)	ng/mL·h	23.6 ± 5.9	207.6 ± 72.9
AUC(0 − ∞)	ng/mL·h	23.7 ± 5.9	208.9 ± 73.1
T1/2z	h	1.3 ± 0.6	3.1 ± 0.4
Vz	L/kg	0.083
CLz	L/h/kg	8.1 ± 4.4
Vz/F	L/kg		2.8 ± 1.8
CLz/F	L/h/kg		117.9 ± 47.3
Cmax	ng/mL	4.4 ± 1.0	26.3 ± 8.6
Bioavailability			17.6%