Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs

Figure 3

Representative MRM chromatograms for pioglitazone, omarigliptin, and IS from (a) blank rat plasma; (b) blank plasma spiked with pioglitazone (5 ng/mL), omarigliptin (10 ng/mL), and IS (50 ng/mL); and (c) plasma from rats at 2 h after oral administration of pioglitazone and omarigliptin.

(a)

(b)

(c)