Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Compounds</td><td class="align_center">Precursor ions</td><td class="align_center">Product ions</td><td class="align_center">CE (V)</td><td class="align_center">RF lens (V)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Pioglitazone</td><td class="align_center">357.1</td><td class="align_center">134.1</td><td class="align_center">29</td><td class="align_center">100</td></tr><tr><td class="align_left">Omarigliptin</td><td class="align_center">399.2</td><td class="align_center">153.0</td><td class="align_center">30</td><td class="align_center">80</td></tr><tr><td class="align_left">Sitagliptin</td><td class="align_center">408.2</td><td class="align_center">235.0</td><td class="align_center">18</td><td class="align_center">80</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Optimized parameters for the detection of pioglitazone, omarigliptin, and sitagliptin (IS).</div>

Journal of Analytical Methods in Chemistry

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Table 2

Table 2: Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs 

Table 2 | Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs 