Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs

Table 4

Recovery and matrix effects of pioglitazone and omarigliptin in rat plasma (n = 6).

Analytes	Concentration	Recovery (%)		Matrix effect (%)
	(ng/mL)	Mean ± SD	RSD (%)	(Mean ± SD)	RSD (%)
Pioglitazone	15	94.56 ± 5.79	6.13	158.98 ± 9.63	6.06
	400	96.45 ± 6.59	6.83	134.90 ± 9.56	7.09
	1500	86.73 ± 5.38	6.20	142.64 ± 8.60	6.03
Omarigliptin	30	94.79 ± 4.59	4.72	113.80 ± 5.40	4.74
	800	96.42 ± 6.19	6.42	108.91 ± 6.89	6.32
	3000	89.11 ± 7.09	7.96	111.84 ± 8.59	7.68
Sitagliptin	50	107.01 ± 2.08	2.04	98.00 ± 2.05	2.09