Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs

<table class="table-group" id="tab7"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2"> </td><td class="align_center"><i>C</i><sub>max</sub></td><td class="align_center"><i>t</i><sub>max</sub></td><td class="align_center"><i>t</i><sub>1/2</sub></td><td class="align_center">AUC<sub>(0−t)</sub></td><td class="align_center">AUC<sub>(0−∞)</sub></td></tr><tr class="thead"><td class="align_center">(ng/mL)</td><td class="align_center">(hour)</td><td class="align_center">(hour)</td><td class="align_center">ng·h/mL</td><td class="align_center">ng·h/mL</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left">Single pioglitazone</td><td class="align_center">2551 ± 475</td><td class="align_center">1.8 ± 0.4</td><td class="align_center">2.8 ± 1.0</td><td class="align_center">16887 ± 2209</td><td class="align_center">16973 ± 2127</td></tr><tr><td class="align_left">Combination</td><td class="align_center">2465 ± 754</td><td class="align_center">2.0 ± 0</td><td class="align_center">2.1 ± 0.2</td><td class="align_center">18988 ± 2582</td><td class="align_center">19013 ± 2604</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Pharmacokinetic parameters of pioglitazone in rats after single or combination administration (<i>n</i> = 5).</div>

Journal of Analytical Methods in Chemistry

tab7

Table 7

Table 7: Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs 

Table 7 | Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs 