Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs

Table 8

Pharmacokinetic parameters of omarigliptin in rats after single or combination administration (n = 5).

	Cmax	tmax	t1/2	AUC(0−t)	AUC(0−∞)
	(ng/mL)	(hour)	(hour)	ng·h/mL	ng·h/mL
Single omarigliptin	2997 ± 394	1.5 ± 0.7	10.9 ± 0.5	36551 ± 4065	37699 ± 4101
Combination	2521 ± 435	1.8 ± 0.4	11.0 ± 1.2	30357 ± 3762	31346 ± 3815