A Fast and Validated HPLC Method for Simultaneous Determination of Dopamine, Dobutamine, Phentolamine, Furosemide, and Aminophylline in Infusion Samples and Injection Formulations

Table 3

Summary of the forced degradation of DPM, DBM, PTM, FSM, and APL.

Compound	Stress condition	Degradation (%)	Peak purity index
DPM hydrochloride	Acidic	3.4	0.9992
	Alkaline	44.6	0.9999
	Oxidative	1.9	1.0000
DBM hydrochloride	Acidic	1.2	0.9998
	Alkaline	51.4	0.9999
	Oxidative	33.7	0.9999
PTM mesylate	Acidic	40.5	0.9998
	Alkaline	42.2	0.9995
	Oxidative	2.3	0.9999
FSM	Acidic	16.1	0.9998
	Alkaline	25.3	0.9999
	Oxidative	7.6	0.9999
APL	Acidic	1.1	1.0000
	Alkaline	4.5	0.9991
	Oxidative	10.6	0.9995