A Fast and Validated HPLC Method for Simultaneous Determination of Dopamine, Dobutamine, Phentolamine, Furosemide, and Aminophylline in Infusion Samples and Injection Formulations

Table 7

Mean concentrations of DPM, DBM, PTM, FSM, and APL in 5% glucose injection with light protection or light exposure at 25°C.

Storage conditions	Time (hours)	DPM	DBM	PTM	FSM	APL
Light protection	0	100.0 ± 0.4	100.0 ± 0.2	100.0 ± 1.1	100.0 ± 0.6	100.0 ± 0.5
	2	100.8 ± 1.2	102.1 ± 1.1	99.5 ± 0.3	100.3 ± 0.2	98.4 ± 1.0
	4	101.6 ± 1.3	101.8 ± 0.6	100.2 ± 1.0	103.0 ± 1.8	99.3 ± 0.2
	8	102.0 ± 0.4	100.9 ± 0.6	101.1 ± 1.2	98.8 ± 2.1	98.7 ± 0.8
	24	101.7 ± 1.5	98.6 ± 1.7	98.8 ± 0.8	98.2 ± 0.8	99.1 ± 0.6
	48	101.6 ± 0.8	101.8 ± 1.3	98.7 ± 1.6	100.0 ± 0.3	98.4 ± 1.5
Light exposure	0	100.0 ± 0.5	100.0 ± 1.0	100.0 ± 0.5	100.0 ± 0.2	100.0 ± 0.7
	2	99.3 ± 1.6	101.6 ± 0.9	98.5 ± 1.9	98.0 ± 1.4	98.0 ± 1.1
	4	100.2 ± 0.9	101.9 ± 0.6	100.9 ± 0.2	98.8 ± 0.6	98.4 ± 0.8
	8	102.3 ± 1.1	99.8 ± 1.0	97.4 ± 2.1	99.4 ± 1.5	98.2 ± 0.4
	24	101.2 ± 0.7	101.8 ± 0.5	98.1 ± 1.7	98.9 ± 1.7	99.1 ± 0.2
	48	101.5 ± 1.1	103.3 ± 2.1	96.7 ± 1.0	97.5 ± 1.9	98.9 ± 1.3