Quantitative Measurement of Plasma Free Metanephrines by a Simple and Cost-Effective Microextraction Packed Sorbent with Porous Graphitic Carbon and Liquid Chromatography-Tandem Mass Spectrometry

Table 2

Comparison of the analytical performance of the developed method with five recently described LC-MS/MS methods for determining the concentrations of metanephrines in human plasma.

Sample preparation	Analyte	LLOQ (nmol/L)	Plasma (μL)	Solvent used during extraction (mL)	Potential interferences test	Evaporation	Injection volume (μL)	Reuse number	Ref.
Ion-paring SPE (HyperSep)	NM	0.037	500	5.6	1	Yes	40	1	He et al. (2011)
	NMN	0.098
SPE (Oasis WCX)	NM	0.020	900	2.7	2	Yes	/	1	Peitzsch et al. (2013)
	NMN	0.024
SPE (Evolute WCX)	NM	0.070	400	3.0	3	No	30	1	Shen et al. (2019)
	NMN	0.060
SPE (oasis WCX μElution)	NM	0.100	200	1.1	28	No	35	1	Petteys et al. (2012)
	NMN	0.100
SPE (Oasis WCX)	NM	0.104	380	1.1	0	No	20	1	Luo et al. (2017)
	NMN	0.109
MEPS (PGC)	NM	0.128	100	0.69	54	No	5	50	This work
	NMN	0.134