Research Article
Quantitation of Apremilast in Beagle Dogs Plasma by UPLC-MS-MS and Its Application to Pharmacokinetic Studies
Table 1
Precision and accuracy of apremilast in beagle dog plasma.
| | Nominal concentration (ng mL−1) | Intraday determination (n = 6) | Interday determination (n = 6) | | Determined concentration (ng mL−1) | Accuracy (%) | R.S.D. (%) | Determined concentration (ng/mL) | Accuracy (%) | R.S.D. (%) |
| | 5 | 5.00 | 100.1 | 5.9 | 4.64 | 92.8 | 5.5 | | 500 | 461.97 | 92.4 | 5.3 | 475.99 | 95.2 | 8.3 | | 1000 | 935.94 | 93.6 | 3.3 | 900.56 | 90.1 | 4.6 |
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